Does Mepivacaine Hydrochloride Interact with Epinephrine?
CDI records a major classification for Mepivacaine Hydrochloride and Epinephrine. The stored summary is: Local anesthetic solutions containing Epinephrine may produce severe, prolonged hypertension in patients receiving tricyclic antidepressants or monoamine oxidase inhibitors; serious cardiac arrhythmias may occur with potent inhalation anesthetics. The mechanism involves vasopressor effect potentiation; interaction with inhalation anesthetics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Epinephrine Class
- alpha-Adrenergic Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Vasopressor effect potentiation; interaction with inhalation anesthetics
What To Tell Your Doctor or Pharmacist
If you are taking Mepivacaine Hydrochloride and your doctor is considering prescribing Epinephrine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider