Meropenem And Sodium Chloride + Valproic Acid Interaction
Majorinteraction on record
Description
Co-administration may reduce valproic acid concentrations below therapeutic range, increasing risk of breakthrough seizures. Mechanism may involve carbapenem inhibition of valproic acid glucuronide metabolite hydrolysis.
Mechanism
Possible inhibition of hydrolysis of valproic acid's glucuronide metabolite back to valproic acid
Source: NLP:meropenem-vaborbactam