Does Metformin Hydrochloride Interact with Glibenclamide?
Metformin Hydrochloride and Glibenclamide have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration resulted in decreases in glyburide AUC and Cmax that were highly variable. Clinical significance uncertain due to single-dose study design and lack of correlation between glyburide blood levels and pharmacodynamic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Glibenclamide Class
- Sulfonylurea
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Metformin Hydrochloride and your doctor is considering prescribing Glibenclamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider