Brand names: Metformin Hydrochloride
10 interactions on record
Nifedipine —A single-dose, metformin-nifedipine drug interaction study in normal healthy volunteers demonstrated that coadministration of nifedipine increased plasma metformin C max and AUC by 20% and 9%, respectively, and increased the amount excreted in the urine. Nifedipine appears to enhance the absorption of metformin. Metformin had minimal effects on nifedipine.
Source: FDA drug label - metformin hcl
Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide.
Source: FDA drug label - metformin hydrochloride
Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide.
Source: FDA drug label - metformin hydrochloride
Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine. Consider more frequent monitoring ( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin.
Source: FDA drug label - metformin hydrochloride
Furosemide —A single-dose, metformin-furosemide drug interaction study in healthy subjects demonstrated that pharmacokinetic parameters of both compounds were affected by coadministration. Furosemide increased the metformin plasma and blood C max by 22% and blood AUC by 15%, without any significant change in metformin renal clearance. When administered with metformin, the C max and AUC of furosemide were 31% and 12% smaller, respectively, than when administered alone, and the terminal half-life was decreased by 32%, without any significant change in furosemide renal clearance.
Source: FDA drug label - metformin hcl
Cationic drugs —Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems.
Source: FDA drug label - metformin hcl
In healthy volunteers, the pharmacokinetics of metformin and propranolol, and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.
Source: FDA drug label - metformin hcl
Cationic drugs —Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems.
Source: FDA drug label - metformin hcl
Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine. Consider more frequent monitoring ( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin.
Source: FDA drug label - metformin hydrochloride
Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide.
Source: FDA drug label - metformin hydrochloride