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Metformin Hydrochloride

Also known as: Kazano, Jentadueto, Kombiglyze, Janumet +10 more

Route: Oral

Check Metformin Hydrochloride Interactions →

38 interactions on record⛔ Black Box Warning

Metformin Hydrochloride has 38 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Alcohol, Cimetidine. Patients taking Metformin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 38
Major: 12
Moderate: 25

Major (12)

Metformin Hydrochloride + Acetazolamide— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…
Metformin Hydrochloride + Alcohol— Potentiates metformin's effect on lactate metabolism, increasing risk of lactic acidosis.
Metformin Hydrochloride + Cimetidine— OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic…
Metformin Hydrochloride + Dichlorphenamide— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…
Metformin Hydrochloride + Dolutegravir— OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic…
Metformin Hydrochloride + Insulin Human— Coadministration with metformin may increase risk of hypoglycemia.
Metformin Hydrochloride + Mao Inhibitors— May increase risk of lactic acidosis with metformin. Consider more frequent monitoring.
Metformin Hydrochloride + Ranolazine— OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic…
Metformin Hydrochloride + Sulfonylurea— Insulin secretagogue that when combined with metformin may increase risk of hypoglycemia.
Metformin Hydrochloride + Topiramate— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…
Metformin Hydrochloride + Vandetanib— OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic…
Metformin Hydrochloride + Zonisamide— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…

Moderate (25)

Metformin Hydrochloride + Amiloride— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Andthiazide— Diuretic that may cause hyperglycemia and loss of glycemic control; monitor blood glucose closely.
Metformin Hydrochloride + Calcium Channel Blockers— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Corticosteroids— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Digoxin— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Estrogens— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Furosemide— Furosemide increased metformin plasma and blood Cmax by 22% and blood AUC by 15%. Metformin decreased furosemide Cmax by…
Metformin Hydrochloride + Glibenclamide— Coadministration resulted in decreases in glyburide AUC and Cmax that were highly variable. Clinical significance uncert…
Metformin Hydrochloride + Isoniazid— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Morphine— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Niacin— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Nifedipine— Nifedipine increased metformin plasma Cmax by 20% and AUC by 9%, with increased urinary excretion. Tmax and half-life un…
Metformin Hydrochloride + Oral Contraceptives— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Phenothiazine Antipsychotics— Produces hyperglycemia and may lead to loss of glycemic control. Monitor blood glucose closely.
Metformin Hydrochloride + Phenothiazines— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Phenytoin— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Procainamide— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Quinidine— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Quinine— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Ranitidine— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Thiazides— Diuretics that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Thyroid— Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.
Metformin Hydrochloride + Triamterene— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Trimethoprim— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
Metformin Hydrochloride + Vancomycin— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…

Metformin Hydrochloride + Acetazolamide⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Metformin Hydrochloride + Alcohol⚠️Major

Potentiates metformin's effect on lactate metabolism, increasing risk of lactic acidosis.

Metformin Hydrochloride + Cimetidine⚠️Major

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic metformin exposure.

Metformin Hydrochloride + Dichlorphenamide⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Metformin Hydrochloride + Dolutegravir⚠️Major

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic metformin exposure.

Metformin Hydrochloride + Insulin Human⚠️Major

Coadministration with metformin may increase risk of hypoglycemia.

Metformin Hydrochloride + Mao Inhibitors⚠️Major

May increase risk of lactic acidosis with metformin. Consider more frequent monitoring.

Metformin Hydrochloride + Ranolazine⚠️Major

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic metformin exposure.

Metformin Hydrochloride + Sulfonylurea⚠️Major

Insulin secretagogue that when combined with metformin may increase risk of hypoglycemia.

Metformin Hydrochloride + Topiramate⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Metformin Hydrochloride + Vandetanib⚠️Major

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk of lactic acidosis through increased systemic metformin exposure.

Metformin Hydrochloride + Zonisamide⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Metformin Hydrochloride + Amiloride🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Andthiazide🟡Moderate

Diuretic that may cause hyperglycemia and loss of glycemic control; monitor blood glucose closely.

Metformin Hydrochloride + Calcium Channel Blockers🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Corticosteroids🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Digoxin🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Estrogens🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Furosemide🟡Moderate

Furosemide increased metformin plasma and blood Cmax by 22% and blood AUC by 15%. Metformin decreased furosemide Cmax by 31%, AUC by 12%, and half-life by 32%. Chronic interaction effects unknown.

Metformin Hydrochloride + Glibenclamide🟡Moderate

Coadministration resulted in decreases in glyburide AUC and Cmax that were highly variable. Clinical significance uncertain due to single-dose study design and lack of correlation between glyburide blood levels and pharmacodynamic effects.

Metformin Hydrochloride + Isoniazid🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Morphine🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Niacin🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Nifedipine🟡Moderate

Nifedipine increased metformin plasma Cmax by 20% and AUC by 9%, with increased urinary excretion. Tmax and half-life unaffected. Metformin had minimal effects on nifedipine.

Metformin Hydrochloride + Oral Contraceptives🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Phenothiazine Antipsychotics🟡Moderate

Produces hyperglycemia and may lead to loss of glycemic control. Monitor blood glucose closely.

Metformin Hydrochloride + Phenothiazines🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Phenytoin🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Procainamide🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Quinidine🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Quinine🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Ranitidine🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Thiazides🟡Moderate

Diuretics that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Thyroid🟡Moderate

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Metformin Hydrochloride + Triamterene🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Trimethoprim🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Vancomycin🟡Moderate

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Metformin Hydrochloride + Propranololℹ️Unknown

In healthy volunteers, the pharmacokinetics of metformin and propranolol, and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.