Does Metformin Hydrochloride Interact with Nifedipine?
CDI records a moderate classification for Metformin Hydrochloride and Nifedipine. The stored summary is: Nifedipine increased metformin plasma Cmax by 20% and AUC by 9%, with increased urinary excretion. Tmax and half-life unaffected. Metformin had minimal effects on nifedipine. The mechanism involves nifedipine appears to enhance metformin absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Nifedipine Class
- Dihydropyridine Calcium Channel Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Nifedipine appears to enhance metformin absorption
What To Tell Your Doctor or Pharmacist
If you are taking Metformin Hydrochloride and your doctor is considering prescribing Nifedipine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider