Does Methotrexate Interact with Daunorubicin Hydrochloride?
CDI records a moderate classification for Methotrexate and Daunorubicin Hydrochloride. The stored summary is: High-dose methotrexate is hepatotoxic and may impair liver function, increasing risk of daunorubicin toxicity. Dosage reduction may be required. The mechanism involves hepatotoxicity impairing liver function and drug clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Hepatotoxicity impairing liver function and drug clearance
What To Tell Your Doctor or Pharmacist
If you are taking Methotrexate and your doctor is considering prescribing Daunorubicin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider