Home›Methotrexate›Methotrexate + Dexlansoprazole

Does Methotrexate Interact with Dexlansoprazole?

Methotrexate and Dexlansoprazole have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, particularly at high doses. The mechanism involves reduced renal clearance of methotrexate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Methotrexate Class
Folate Analog Metabolic Inhibitor
Dexlansoprazole Class
Proton Pump Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Methotrexate and Dexlansoprazole occurs because reduced renal clearance of methotrexate. Clinically, this means concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, particularly at high doses. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Methotrexate and your doctor is considering prescribing Dexlansoprazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Methotrexate(Otrexup)+💊 Dexlansoprazole(Dexilant)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Folate Analog Metabolic Inhibitor
Drug B class
Proton Pump Inhibitor
Source
NLP:dexlansoprazole

What this means in plain English

Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, particularly at high doses.

About Methotrexate and Dexlansoprazole

Methotrexate is a Folate Analog Metabolic Inhibitor, while Dexlansoprazole is a Proton Pump Inhibitor. You may recognize them by the brand names Otrexup and Dexilant. Methotrexate is given by intramuscular injection, whereas Dexlansoprazole is taken by mouth. Methotrexate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Reduced renal clearance of methotrexate"

📖 Source: NLP:dexlansoprazole

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Methotrexate and Dexlansoprazole against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.