Does Methsuximide Interact with Phenobarbital?
CDI records a moderate classification for Methsuximide and Phenobarbital. The stored summary is: Methsuximide may increase plasma concentrations of phenobarbital; periodic serum level determinations may be necessary. The mechanism involves methsuximide increases plasma concentrations of phenobarbital. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Methsuximide Class
- Anti-epileptic Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Methsuximide increases plasma concentrations of phenobarbital
What To Tell Your Doctor or Pharmacist
If you are taking Methsuximide and your doctor is considering prescribing Phenobarbital (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider