Does Midazolam Injection 10 Mg Interact with Diltiazem?
Midazolam Injection 10 Mg and Diltiazem have a moderate drug interaction according to U.S. FDA drug labeling data. May result in prolonged sedation due to decreased plasma clearance of midazolam. The mechanism involves inhibition of cytochrome p450-3a4 enzyme system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Midazolam Injection 10 Mg Class
- Benzodiazepine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Midazolam Injection 10 Mg and Diltiazem occurs because inhibition of cytochrome p450-3a4 enzyme system. Clinically, this means may result in prolonged sedation due to decreased plasma clearance of midazolam. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Midazolam Injection 10 Mg and your doctor is considering prescribing Diltiazem (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider