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Midazolam Injection, 10 Mg

Also known as: N/A

Benzodiazepine

Route: Intramuscular

Check Midazolam Injection, 10 Mg Interactions →

13 interactions on record⛔ Black Box Warning

Midazolam Injection, 10 Mg has 13 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Droperidol, Fentanyl. Patients taking Midazolam Injection, 10 Mg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 13
Major: 6
Moderate: 7

Major (6)

Midazolam Injection, 10 Mg + Alcohol— Concomitant use accentuates sedative effect of midazolam through CNS depression.
Midazolam Injection, 10 Mg + Droperidol— Concomitant use accentuates sedative effect of midazolam through CNS depression.
Midazolam Injection, 10 Mg + Fentanyl— Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respirator…
Midazolam Injection, 10 Mg + Meperidine— Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respirator…
Midazolam Injection, 10 Mg + Morphine— Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respirator…
Midazolam Injection, 10 Mg + Secobarbital— Concomitant use accentuates sedative effect of midazolam through CNS depression.

Moderate (7)

Midazolam Injection, 10 Mg + Cimetidine— May result in prolonged sedation due to decreased plasma clearance of midazolam.
Midazolam Injection, 10 Mg + Diltiazem— May result in prolonged sedation due to decreased plasma clearance of midazolam.
Midazolam Injection, 10 Mg + Erythromycin— Cytochrome P450-3A4 Inhibitors Caution is advised when Midazolam Injection is administered concomitantly with drugs that…
Midazolam Injection, 10 Mg + Itraconazole— Cytochrome P450-3A4 Inhibitors Caution is advised when Midazolam Injection is administered concomitantly with drugs that…
Midazolam Injection, 10 Mg + Ketoconazole— Cytochrome P450-3A4 Inhibitors Caution is advised when Midazolam Injection is administered concomitantly with drugs that…
Midazolam Injection, 10 Mg + Midazolam— Other CNS Depressants and Alcohol The sedative effect of Midazolam Injection is accentuated by concomitantly administere…
Midazolam Injection, 10 Mg + Verapamil— May result in prolonged sedation due to decreased plasma clearance of midazolam.

Midazolam Injection, 10 Mg + Alcohol⚠️Major

Concomitant use accentuates sedative effect of midazolam through CNS depression.

Midazolam Injection, 10 Mg + Droperidol⚠️Major

Concomitant use accentuates sedative effect of midazolam through CNS depression.

Midazolam Injection, 10 Mg + Fentanyl⚠️Major

Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respiratory depression and sedation.

Midazolam Injection, 10 Mg + Meperidine⚠️Major

Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respiratory depression and sedation.

Midazolam Injection, 10 Mg + Morphine⚠️Major

Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respiratory depression and sedation.

Midazolam Injection, 10 Mg + Secobarbital⚠️Major

Concomitant use accentuates sedative effect of midazolam through CNS depression.

Midazolam Injection, 10 Mg + Cimetidine🟡Moderate

May result in prolonged sedation due to decreased plasma clearance of midazolam.

Midazolam Injection, 10 Mg + Diltiazem🟡Moderate

May result in prolonged sedation due to decreased plasma clearance of midazolam.

Midazolam Injection, 10 Mg + Erythromycin🟡Moderate

Cytochrome P450-3A4 Inhibitors Caution is advised when Midazolam Injection is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system (e.g., cimetidine, erythromycin, diltiazem, verapamil, ketoconazole, and itraconazole).

Midazolam Injection, 10 Mg + Itraconazole🟡Moderate

Midazolam Injection, 10 Mg + Ketoconazole🟡Moderate

Midazolam Injection, 10 Mg + Midazolam🟡Moderate

Other CNS Depressants and Alcohol The sedative effect of Midazolam Injection is accentuated by concomitantly administered medication that depresses the central nervous system, particularly opioids (e.g., morphine, meperidine, and fentanyl), secobarbital, and droperidol, and also by alcohol [see Warnings and Precautions (5.1, 5.4, 5.6)]. Cytochrome P450-3A4 Inhibitors Caution is advised when Midazolam Injection is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system (e.g., cimetidine, erythromycin, diltiazem, verapamil, ketoconazole, and itraconazole). These drug interactions may result in prolonged sedation caused by a decrease in plasma clearance of midazolam [see Clinical Pharmacology (12.3)].

Midazolam Injection, 10 Mg + Verapamil🟡Moderate

May result in prolonged sedation due to decreased plasma clearance of midazolam.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.