Does Monoamine Oxidase Inhibitors Maois Interact with Carvedilol?
CDI records a major classification for Monoamine Oxidase Inhibitors Maois and Carvedilol. The stored summary is: May increase risk of hypotension and/or severe bradycardia through catecholamine depletion combined with beta-blockade. The mechanism involves catecholamine depletion combined with beta-blockade. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Carvedilol Class
- alpha-Adrenergic Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Catecholamine depletion combined with beta-blockade
What To Tell Your Doctor or Pharmacist
If you are taking Monoamine Oxidase Inhibitors Maois and your doctor is considering prescribing Carvedilol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider