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Does Moxidectin Interact with Midazolam?

Moxidectin and Midazolam have a minor drug interaction according to U.S. FDA drug labeling data. Concomitant administration of moxidectin 8 mg oral dose did not have an effect on midazolam pharmacokinetics in healthy subjects. The mechanism involves cyp3a4 substrate interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Midazolam Class
Benzodiazepine
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Moxidectin and Midazolam occurs because cyp3a4 substrate interaction. Clinically, this means concomitant administration of moxidectin 8 mg oral dose did not have an effect on midazolam pharmacokinetics in healthy subjects. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.

What To Tell Your Doctor or Pharmacist

If you are taking Moxidectin and your doctor is considering prescribing Midazolam (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Moxidectin(Cydectin)+💊 Midazolam(Nayzilam)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Benzodiazepine
Source
NLP:moxidectin

What this means in plain English

Concomitant administration of moxidectin 8 mg oral dose did not have an effect on midazolam pharmacokinetics in healthy subjects.

About Moxidectin and Midazolam

Midazolam is a Benzodiazepine. You may recognize them by the brand names Cydectin and Nayzilam. Moxidectin is taken by mouth, whereas Midazolam is given by intravenous (IV) infusion. Midazolam additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"CYP3A4 substrate interaction"

📖 Source: NLP:moxidectin

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.