Does Mycophenolate Mofetil Hydrochloride Interact with Cyclosporine?
CDI records a moderate classification for Mycophenolate Mofetil Hydrochloride and Cyclosporine. The stored summary is: Interferes with enterohepatic recirculation, decreasing mycophenolic acid systemic exposure and potentially reducing Mycophenolate Mofetil efficacy. Monitor for alterations. The mechanism involves interference with enterohepatic recirculation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Interference with enterohepatic recirculation
What To Tell Your Doctor or Pharmacist
If you are taking Mycophenolate Mofetil Hydrochloride and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider