Does Naltrexone Hydrochloride And Bupropion Hydrochloride Interact with Opioid Analgesics?
Naltrexone Hydrochloride And Bupropion Hydrochloride and Opioid Analgesics have a moderate drug interaction according to U.S. FDA drug labeling data. Patients may not fully benefit from opioid-containing medicines. CONTRAVE therapy should be temporarily discontinued for intermittent opiate treatment. May be used with caution after chronic opioid use stopped for 7-10 days to prevent withdrawal precipitation. The mechanism involves naltrexone antagonism of opioid effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Naltrexone Hydrochloride And Bupropion Hydrochloride and Opioid Analgesics occurs because naltrexone antagonism of opioid effects. Clinically, this means patients may not fully benefit from opioid-containing medicines. contrave therapy should be temporarily discontinued for intermittent opiate treatment. may be used with caution after chronic opioid use stopped for 7-10 days to prevent withdrawal precipitation. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Naltrexone Hydrochloride And Bupropion Hydrochloride and your doctor is considering prescribing Opioid Analgesics (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider