Opioid Analgesics Interactions

Concomitant use may result in profound sedation, respiratory depression, coma, or death. May prolong recovery time from anesthesia.

Source: NLP:ketamine hydrochloride

Narcotic analgesics may enhance effects causing increased CNS depression.

Source: NLP:butalbital, acetaminophen, and caffeine

Causes increased CNS depression.

Source: NLP:butalbital, aspirin, and caffeine

May potentiate or be potentiated by diazepam action, increasing respiratory depression risk. Careful consideration required.

Source: NLP:diazepam

Produces increased CNS-depressant effects including respiratory depression and sedation.

Source: NLP:lorazepam

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive pharmacologic effects.

Source: NLP:nalbuphine hydrochloride

Patients may not benefit from opioid analgesia. Amount required may be greater than usual with deeper and more prolonged respiratory depression.

Source: NLP:naltrexone hydrochloride

Promethazine may increase, prolong, or intensify the sedative action; doses should be reduced by one-quarter to one-half.

Source: NLP:promethazine hydrochloride

Promethazine may increase, prolong, or intensify sedative action. Dose reduction recommended when given concomitantly.

Source: NLP:promethazine hydrochloride and dextromethorphan hydrobromide

Produces additive CNS-depressant effects when co-administered with temazepam.

Source: NLP:temazepam

Butalbital and acetaminophen may enhance the effects of other narcotic analgesics, causing increased CNS depression.

Source: NLP:butalbital and acetaminophen

Concomitant use may increase risk of water intoxication with hyponatremia; requires more frequent serum sodium monitoring.

Source: NLP:desmopressin acetate

Additive CNS depressant effects; reduced dosage of hydromorphone recommended to avoid excessive effects.

Source: NLP:hydromorphone hydrochloride

Drug interactions may occur when hyoscyamine sulfate is used with opioid analgesics.

Source: NLP:hyoscyamine sulfate

May result in increased risk of severe constipation.

Source: NLP:methenamine, sodium phosphate, monobasic, anhydrous, phenyl salicylate, methylene blue and hyoscyamine sulfate

Narcotic analgesics antagonize the effects of metoclopramide on gastrointestinal motility.

Source: NLP:metoclopramide

Narcotic analgesics antagonize the effects of metoclopramide on gastrointestinal motility.

Source: NLP:metoclopramide hydrochloride

Promethazine may increase, prolong, or intensify sedative action; dose should be reduced by one-quarter to one-half.

Source: NLP:promethazine hydrochloride and phenylephrine hydrochloride