Opioid Analgesics has 31 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ketamine Hydrochloride, Butalbital, Acetaminophen And Caffeine, Butalbital, Aspirin, And Caffeine. Patients taking Opioid Analgesics should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Contraindicated
- 1
- Major
- 12
- Moderate
- 18
Contraindicated (1)
- Opioid Analgesics + Ketamine Hydrochloride— Concomitant use may result in profound sedation, respiratory depression, coma, or death. May prolong recovery time from …
Major (12)
- Opioid Analgesics + Butalbital, Acetaminophen And Caffeine— Narcotic analgesics may enhance effects causing increased CNS depression.
- Opioid Analgesics + Butalbital, Aspirin, And Caffeine— Causes increased CNS depression.
- Opioid Analgesics + Diazepam— May potentiate or be potentiated by diazepam action, increasing respiratory depression risk. Careful consideration requi…
- Opioid Analgesics + Lorazepam— Produces increased CNS-depressant effects including respiratory depression and sedation.
- Opioid Analgesics + Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate— May result in increased risk of severe constipation.
- Opioid Analgesics + Nalbuphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive pharmacolog…
- Opioid Analgesics + Naltrexone— Naltrexone antagonizes the effects of opioid analgesics, preventing their therapeutic benefit.
- Opioid Analgesics + Naltrexone Hydrochloride— Patients may not benefit from opioid analgesia. Amount required may be greater than usual with deeper and more prolonged…
- Opioid Analgesics + Promethazine Hydrochloride— Promethazine may increase, prolong, or intensify the sedative action; doses should be reduced by one-quarter to one-half…
- Opioid Analgesics + Promethazine Hydrochloride And Dextromethorphan Hydrobromide— Promethazine may increase, prolong, or intensify sedative action. Dose reduction recommended when given concomitantly.
- Opioid Analgesics + Temazepam— Produces additive CNS-depressant effects when co-administered with temazepam.
- Opioid Analgesics + Urinary Antiseptic Antispasmodic— May result in increased risk of severe constipation due to reduced intestinal motility.
Moderate (18)
- Opioid Analgesics + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Additive CNS depressant effects when combined with dihydrocodeine; dose reduction of one or both agents recommended.
- Opioid Analgesics + Butalbital And Acetaminophen— Butalbital and acetaminophen may enhance the effects of other narcotic analgesics, causing increased CNS depression.
- Opioid Analgesics + Butalbital And Acetaminophen Tablets— Other narcotic analgesics may have enhanced effects when combined with butalbital and acetaminophen, causing increased C…
- Opioid Analgesics + Butalbital, Acetaminophen, And Caffeine Capsules— Narcotic analgesics may have enhanced effects when combined, causing increased CNS depression.
- Opioid Analgesics + Clonidine— Narcotic analgesics may potentiate the hypotensive effects of clonidine.
- Opioid Analgesics + Clonidine Hydrochloride— Narcotic analgesics may potentiate the hypotensive effects of clonidine.
- Opioid Analgesics + Desmopressin Acetate— Concomitant use may increase risk of water intoxication with hyponatremia; requires more frequent serum sodium monitorin…
- Opioid Analgesics + Desmopressin Acetate Oral Solution— May increase risk of water intoxication with hyponatremia. Monitor serum sodium more frequently.
- Opioid Analgesics + Hydrocodone Bitartrate And Acetaminophen— Concomitant use may exhibit additive CNS depression; dose of one or both agents should be reduced.
- Opioid Analgesics + Hydromorphone Hydrochloride— Additive CNS depressant effects; reduced dosage of hydromorphone recommended to avoid excessive effects.
- Opioid Analgesics + Hyoscyamine Sulfate— Drug interactions may occur when hyoscyamine sulfate is used with opioid analgesics.
- Opioid Analgesics + Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate— May result in increased risk of severe constipation.
- Opioid Analgesics + Metoclopramide— Narcotic analgesics antagonize the effects of metoclopramide on gastrointestinal motility.
- Opioid Analgesics + Metoclopramide Hydrochloride— Narcotic analgesics antagonize the effects of metoclopramide on gastrointestinal motility.
- Opioid Analgesics + Naltrexone Hydrochloride And Bupropion Hydrochloride— Patients may not fully benefit from opioid-containing medicines. CONTRAVE therapy should be temporarily discontinued for…
- Opioid Analgesics + Pramlintide Acetate— SYMLIN may delay absorption of oral analgesics. Administer at least 1 hour prior to or 2 hours after SYMLIN injection.
- Opioid Analgesics + Promethazine Hydrochloride And Phenylephrine Hydrochloride— Promethazine may increase, prolong, or intensify sedative action; dose should be reduced by one-quarter to one-half.
- Opioid Analgesics + Remimazolam Besylate— Sedative effect of remimazolam besylate can be accentuated by opioid analgesics. Dose titration required with continuous…