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Does Natalizumab Sztn Interact with Cyclosporine?

Natalizumab Sztn and Cyclosporine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Should not be used concomitantly with natalizumab due to increased risk of PML and other infections in Crohn's disease patients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Natalizumab Sztn Class
Integrin Receptor Antagonist
Cyclosporine Class
Calcineurin Inhibitor Immunosuppressant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Natalizumab Sztn and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Natalizumab Sztn(Tyruko)+💊 Cyclosporine(Neoral)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Integrin Receptor Antagonist
Drug B class
Calcineurin Inhibitor Immunosuppressant
Source
NLP:natalizumab-sztn

What this means in plain English

Should not be used concomitantly with natalizumab due to increased risk of PML and other infections in Crohn's disease patients.

About Natalizumab Sztn and Cyclosporine

Natalizumab Sztn is an Integrin Receptor Antagonist, while Cyclosporine is a Calcineurin Inhibitor Immunosuppressant. You may recognize them by the brand names Tyruko and Neoral. Natalizumab Sztn is given by intravenous (IV) infusion, whereas Cyclosporine is taken by mouth. Both Natalizumab Sztn and Cyclosporine carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.