Nefazodone + Ado Trastuzumab Emtansine Interaction
Majorinteraction on record
Description
Strong CYP3A4 inhibitor that may increase DM1 exposure and toxicity. Concomitant use should be avoided or KADCYLA treatment delayed.
Mechanism
Inhibition of CYP3A4-mediated metabolism of DM1
Source: NLP:ado-trastuzumab emtansine