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Does Nefazodone Hydrochloride Interact with Buspirone?

Nefazodone Hydrochloride and Buspirone have a major drug interaction according to U.S. FDA drug labeling data. Marked increases in buspirone plasma concentrations (up to 20-fold in Cmax, 50-fold in AUC) with significant decreases in metabolite. Subjects experienced lightheadedness, asthenia, dizziness, somnolence. The mechanism involves inhibition of buspirone metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Nefazodone Hydrochloride and Buspirone occurs because inhibition of buspirone metabolism. Clinically, this means marked increases in buspirone plasma concentrations (up to 20-fold in cmax, 50-fold in auc) with significant decreases in metabolite. subjects experienced lightheadedness, asthenia, dizziness, somnolence. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Nefazodone Hydrochloride and your doctor is considering prescribing Buspirone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Nefazodone Hydrochloride(Nefazodone Hydrochloride)+💊 Buspirone(Buspirone Hydrochloride)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:nefazodone hydrochloride

What this means in plain English

Marked increases in buspirone plasma concentrations (up to 20-fold in Cmax, 50-fold in AUC) with significant decreases in metabolite. Subjects experienced lightheadedness, asthenia, dizziness, somnolence.

What the FDA label says

"Inhibition of buspirone metabolism"

📖 Source: NLP:nefazodone hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.