Does Nevirapine Interact with Efavirenz?
Nevirapine and Efavirenz have a unknown drug interaction according to U.S. FDA drug labeling data. Nevirapine decreases efavirenz concentrations. No appropriate doses established for safe and effective use of this combination. The mechanism involves cyp3a/2b6 enzyme induction by nevirapine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Nevirapine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Efavirenz Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nevirapine and Efavirenz occurs because cyp3a/2b6 enzyme induction by nevirapine. Clinically, this means nevirapine decreases efavirenz concentrations. no appropriate doses established for safe and effective use of this combination.
What To Tell Your Doctor or Pharmacist
If you are taking Nevirapine and your doctor is considering prescribing Efavirenz (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider