Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Olmesartan Medoxomil And Hydrochlorothiazide?
Nonsteroidal Anti Inflammatory Drugs Nsaids and Olmesartan Medoxomil And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. NSAIDs may reduce diuretic, natriuretic, and antihypertensive effects; increased risk of renal toxicity and acute renal failure, particularly in elderly, volume-depleted, or renal-compromised patients. The mechanism involves nsaids impair renal function and attenuate effects of angiotensin ii receptor antagonists and thiazide diuretics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Olmesartan Medoxomil And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nonsteroidal Anti Inflammatory Drugs Nsaids and Olmesartan Medoxomil And Hydrochlorothiazide occurs because nsaids impair renal function and attenuate effects of angiotensin ii receptor antagonists and thiazide diuretics. Clinically, this means nsaids may reduce diuretic, natriuretic, and antihypertensive effects; increased risk of renal toxicity and acute renal failure, particularly in elderly, volume-depleted, or renal-compromised patients. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Olmesartan Medoxomil And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider