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Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Amlodipine And Benazepril Hydrochloride?

Nonsteroidal Anti Inflammatory Drugs Nsaids and Amlodipine And Benazepril Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. NSAIDs may result in deterioration of renal function and loss of antihypertensive effect with benazepril, especially in elderly or volume-depleted patients. The mechanism involves reduced renal perfusion and prostaglandin inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Nonsteroidal Anti Inflammatory Drugs Nsaids and Amlodipine And Benazepril Hydrochloride occurs because reduced renal perfusion and prostaglandin inhibition. Clinically, this means nsaids may result in deterioration of renal function and loss of antihypertensive effect with benazepril, especially in elderly or volume-depleted patients. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Amlodipine And Benazepril Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Nonsteroidal Anti Inflammatory Drugs Nsaids+💊 Amlodipine And Benazepril Hydrochloride(Amlodipine And Benazepril Hydrochloride)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:amlodipine besylate and benazepril hydrochloride

What this means in plain English

NSAIDs may result in deterioration of renal function and loss of antihypertensive effect with benazepril, especially in elderly or volume-depleted patients.

What the FDA label says

"Reduced renal perfusion and prostaglandin inhibition"

📖 Source: NLP:amlodipine besylate and benazepril hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.