Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Telmisartan And Hydrochlorothiazide?
Nonsteroidal Anti Inflammatory Drugs Nsaids and Telmisartan And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. NSAIDs may result in deterioration of renal function, including possible acute renal failure, and may attenuate the antihypertensive effect of ARBs. NSAIDs reduce diuretic, natriuretic, and antihypertensive effects. The mechanism involves nsaids antagonize effects of arbs and diuretics; renal impairment risk in elderly, volume-depleted, or renally compromised patients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Telmisartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nonsteroidal Anti Inflammatory Drugs Nsaids and Telmisartan And Hydrochlorothiazide occurs because nsaids antagonize effects of arbs and diuretics; renal impairment risk in elderly, volume-depleted, or renally compromised patients. Clinically, this means nsaids may result in deterioration of renal function, including possible acute renal failure, and may attenuate the antihypertensive effect of arbs. nsaids reduce diuretic, natriuretic, and antihypertensive effects. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Telmisartan And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider