Does Norethindrone Acetateethinyl Estradiol Interact with Itraconazole?
Norethindrone Acetateethinyl Estradiol and Itraconazole have a moderate drug interaction according to U.S. FDA drug labeling data. CYP3A4 inhibitor may increase plasma concentration of estrogen or progestin and may result in adverse reactions. The mechanism involves inhibition of cyp3a4 metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Norethindrone Acetateethinyl Estradiol Class
- Estrogen
- Itraconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Norethindrone Acetateethinyl Estradiol and Itraconazole occurs because inhibition of cyp3a4 metabolism. Clinically, this means cyp3a4 inhibitor may increase plasma concentration of estrogen or progestin and may result in adverse reactions. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Norethindrone Acetateethinyl Estradiol and your doctor is considering prescribing Itraconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider