Nsaids + Valsartan And Hydrochlorothiazide Interaction
Majorinteraction on record
Description
NSAIDs with valsartan may result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renal-compromised patients. Antihypertensive effect may be attenuated.
Mechanism
NSAIDs reduce renal perfusion and antagonize angiotensin II receptor blockade
Source: NLP:valsartan and hydrochlorothiazide