Nsaids Interactions

Risk of renal dysfunction and acute renal failure, especially in elderly, volume-depleted, or renal-impaired patients. Antihypertensive effect may be attenuated.

Source: NLP:amlodipine besylate and benazepril hydrochloride

In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. NSAIDs may attenuate antihypertensive effect. Monitor renal function.

Source: NLP:amlodipine and valsartan

May result in deterioration of renal function, acute renal failure, and attenuation of antihypertensive effect of olmesartan. Monitor renal function periodically.

Source: NLP:amlodipine and olmesartan medoxomil

Concurrent use of aspirin with other NSAIDs may increase bleeding risk or decrease renal function.

Source: NLP:aspirin and dipyridamole

Concurrent use with aspirin may increase bleeding risk or lead to decreased renal function.

Source: NLP:aspirin and extended-release dipyridamole

NSAIDs increase risk of renal dysfunction and acute renal failure when combined with azilsartan, particularly in elderly, volume-depleted, or renally impaired patients. NSAIDs also attenuate antihypertensive effect.

Source: NLP:azilsartan kamedoxomil and chlorthalidone

Increased risk of renal impairment, acute renal failure, and loss of antihypertensive efficacy, especially in elderly, volume-depleted, or renal-compromised patients.

Source: NLP:benazepril hydrochloride

May result in deterioration of renal function, possible acute renal failure, and attenuation of antihypertensive effect, especially in elderly, volume-depleted, or renally compromised patients.

Source: NLP:candesartan

May result in deterioration of renal function, including possible acute renal failure, and may attenuate antihypertensive effect. Risk increased in elderly, volume-depleted, or renal-compromised patients.

Source: NLP:candesartan cilexetil

Coadministration in elderly, volume-depleted, or renal-compromised patients may result in deterioration of renal function including acute renal failure. NSAIDs may attenuate antihypertensive effect.

Source: NLP:captopril

Concurrent use of NSAIDs with citalopram may potentiate the risk of upper gastrointestinal bleeding due to interference with serotonin reuptake and platelet hemostasis.

Source: NLP:citalopram

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to interference with hemostasis and serotonin reuptake inhibition.

Source: NLP:citalopram hydrobromide

Increases risk of gastrointestinal bleeding when coadministered with clopidogrel.

Source: NLP:clopidogrel bisulfate

May result in deterioration of renal function, including acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. NSAIDs may also diminish antihypertensive effect.

Source: NLP:enalapril

Co-administration may result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Monitor renal function periodically.

Source: NLP:enalapril maleate

Chronic NSAID use increases the risk of bleeding when coadministered.

Source: NLP:eptifibatide

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to interference with hemostasis.

Source: NLP:escitalopram

Concurrent use with fluoxetine may potentiate risk of upper gastrointestinal bleeding due to fluoxetine's effect on platelet serotonin.

Source: NLP:fluoxetine

Coadministration may result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Antihypertensive effect may be attenuated.

Source: NLP:irbesartan

NSAIDs can reduce diuretic and natriuretic effects, and may lead to renal impairment and reduced antihypertensive effect. Monitor renal function periodically.

Source: NLP:irbesartan and hydrochlorothiazide

May result in deterioration of renal function including possible acute renal failure, especially in elderly or volume-depleted patients. Attenuates antihypertensive effect. Monitor renal function periodically.

Source: NLP:lisinopril

NSAIDs may result in deterioration of renal function, including possible acute renal failure, in elderly patients, volume-depleted patients, or those with compromised renal function. NSAIDs may also attenuate the antihypertensive effect.

Source: NLP:lisinopril and hydrochlorothiazide

May result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally impaired patients. Antihypertensive effect may be attenuated.

Source: NLP:losartan potassium

May result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Antihypertensive effect may be attenuated.

Source: NLP:losartan potassium and hydrochlorothiazide

Increased risk of nephrotoxicity with concurrent use; monitor renal function and mesalamine-related adverse reactions.

Source: NLP:mesalamine

High-dose concurrent use reported to elevate and prolong serum methotrexate levels, causing deaths from severe hematologic and gastrointestinal toxicity. Lower doses require caution.

Source: NLP:methotrexate

Co-administration may result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renally impaired patients. Antihypertensive effect may be attenuated.

Source: NLP:olmesartan medoxomil

May lead to increased risk of renal impairment, loss of antihypertensive effect, and deterioration of renal function including possible acute renal failure.

Source: NLP:olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide

Reduced diuretic, natriuretic and antihypertensive effects; increased risk of renal toxicity and acute renal failure, especially in elderly or volume-depleted patients.

Source: NLP:olmesartan medoxomil and hydrochlorothiazide

Co-administration may result in deterioration of renal function, including possible acute renal failure, and may attenuate antihypertensive effects. Monitor renal function and blood pressure.

Source: NLP:olmesartan medoxomil-hydrochlorothiazide

May result in deterioration of renal function, acute renal failure, and attenuation of antihypertensive effect, especially in elderly, volume-depleted, or renal-compromised patients.

Source: NLP:ramipril

May result in worsening renal function, including acute renal failure, especially in elderly, volume-depleted, or renally compromised patients.

Source: NLP:sacubitril and valsartan

NSAIDs with telmisartan may cause renal function deterioration, including acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Antihypertensive effect may be attenuated.

Source: NLP:telmisartan

Co-administration with trandolapril may result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renal-impaired patients.

Source: NLP:trandolapril

May result in deterioration of renal function including acute renal failure, especially in elderly or volume-depleted patients. Antihypertensive effect may be attenuated. Monitor renal function periodically.

Source: NLP:valsartan

NSAIDs with valsartan may result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renal-compromised patients. Antihypertensive effect may be attenuated.

Source: NLP:valsartan and hydrochlorothiazide

Increased risk of upper gastrointestinal bleeding due to impaired serotonin reuptake affecting platelet hemostasis.

Source: NLP:venlafaxine hydrochloride

Concurrent use may increase risk of renal reactions and nephrotoxicity. Monitor for changes in renal function and mesalamine-related adverse reactions.

Source: NLP:balsalazide disodium

May increase risk of water intoxication with hyponatremia; concomitant administration should be performed with caution.

Source: NLP:desmopressin acetate

Concomitant administration may result in increased NSAID adverse effects due to systemic exposure of diclofenac.

Source: NLP:diclofenac sodium

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to effects on serotonin-mediated platelet function.

Source: NLP:duloxetine

Concurrent use may potentiate risk of upper gastrointestinal bleeding due to serotonin reuptake inhibition effects on platelet function.

Source: NLP:duloxetine hydrochloride

Use with caution; concurrent use may potentiate the risk of upper gastrointestinal bleeding.

Source: NLP:escitalopram oxalate

Concurrent use may potentiate risk of upper gastrointestinal bleeding.

Source: NLP:fluoxetine hydrochloride

May increase the glucose-lowering effect of glimepiride due to high protein binding, increasing susceptibility to hypoglycemia.

Source: NLP:glimepiride

Antiplatelet drugs that may potentiate bleeding risk when used with levomilnacipran. Closely monitor for bleeding.

Source: NLP:levomilnacipran hydrochloride

NSAIDs decrease renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations. Frequent monitoring and dosage adjustment recommended.

Source: NLP:lithium carbonate

May potentiate risk of bleeding when used with olanzapine and fluoxetine.

Source: NLP:olanzapine and fuoxetine

Bleeding reported in patients treated with pentoxifylline with or without concomitant NSAIDs.

Source: NLP:pentoxifylline

May produce unfavorable interactions with potassium supplements, risk of hyperkalemia.

Source: NLP:potassium bicarbonate

Monitor for hyperkalemia. NSAIDs impair renal prostaglandin synthesis and the renin-angiotensin system, causing potassium retention.

Source: NLP:potassium chloride

Chronic coadministration may increase the risk of bleeding.

Source: NLP:prasugrel

NSAIDs may reduce the diuretic, natriuretic, and antihypertensive effect of spironolactone. Monitor closely for desired diuretic effect.

Source: NLP:spironolactone