Does Ofloxacin Interact with Probenecid?
Ofloxacin and Probenecid have a unknown drug interaction according to U.S. FDA drug labeling data. Probenecid has been reported to affect renal tubular secretion of certain quinolones. Effect on ofloxacin elimination has not been studied. The mechanism involves renal tubular secretion interference. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Ofloxacin Class
- Quinolone Antimicrobial
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ofloxacin and Probenecid occurs because renal tubular secretion interference. Clinically, this means probenecid has been reported to affect renal tubular secretion of certain quinolones. effect on ofloxacin elimination has not been studied.
What To Tell Your Doctor or Pharmacist
If you are taking Ofloxacin and your doctor is considering prescribing Probenecid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider