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Does Probenecid Interact with Amoxicillin And Clavulanate Potassium?

Probenecid and Amoxicillin And Clavulanate Potassium have a contraindicated drug interaction according to U.S. FDA drug labeling data. Probenecid decreases renal tubular secretion of amoxicillin, resulting in increased and prolonged blood concentrations. Co-administration is not recommended. The mechanism involves decreased renal tubular secretion of amoxicillin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Amoxicillin And Clavulanate Potassium Class
beta Lactamase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Probenecid and Amoxicillin And Clavulanate Potassium occurs because decreased renal tubular secretion of amoxicillin. Clinically, this means probenecid decreases renal tubular secretion of amoxicillin, resulting in increased and prolonged blood concentrations. co-administration is not recommended. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Probenecid and your doctor is considering prescribing Amoxicillin And Clavulanate Potassium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Probenecid(Probenecid)+💊 Amoxicillin And Clavulanate Potassium(Amoxicillin And Clavulanate Potassium)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
beta Lactamase Inhibitor
Source
NLP:amoxicillin and clavulanate potassium

What this means in plain English

Probenecid decreases renal tubular secretion of amoxicillin, resulting in increased and prolonged blood concentrations. Co-administration is not recommended.

What the FDA label says

"Decreased renal tubular secretion of amoxicillin"

📖 Source: NLP:amoxicillin and clavulanate potassium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.