Does Olmesartan Medoxomil And Hydrochlorothiazide Interact with Nsaids?
Olmesartan Medoxomil And Hydrochlorothiazide and Nsaids have a major drug interaction according to U.S. FDA drug labeling data. Reduced diuretic, natriuretic and antihypertensive effects; increased risk of renal toxicity and acute renal failure, especially in elderly or volume-depleted patients. The mechanism involves nsaids reduce antihypertensive effect and may deteriorate renal function when combined with angiotensin ii receptor antagonists or thiazide diuretics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Olmesartan Medoxomil And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Olmesartan Medoxomil And Hydrochlorothiazide and Nsaids occurs because nsaids reduce antihypertensive effect and may deteriorate renal function when combined with angiotensin ii receptor antagonists or thiazide diuretics. Clinically, this means reduced diuretic, natriuretic and antihypertensive effects; increased risk of renal toxicity and acute renal failure, especially in elderly or volume-depleted patients. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Olmesartan Medoxomil And Hydrochlorothiazide and your doctor is considering prescribing Nsaids (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider