Does Opicapone Interact with Isocarboxazid?
CDI records a contraindicated classification for Opicapone and Isocarboxazid. The stored summary is: Non-selective MAO inhibitor that inhibits catecholamine metabolism. Concomitant use may increase risk of arrhythmias, increased heart rate, and excessive blood pressure changes. The mechanism involves both drugs inhibit catecholamine metabolism, leading to increased catecholamine levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Opicapone Class
- Catechol-O-Methyltransferase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Both drugs inhibit catecholamine metabolism, leading to increased catecholamine levels
What To Tell Your Doctor or Pharmacist
If you are taking Opicapone and your doctor is considering prescribing Isocarboxazid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider