Oral Anticoagulants + Metronidazole Interaction
Majorinteraction on record
Description
Metronidazole potentiates the anticoagulant effect of oral coumarin anticoagulants, resulting in prolongation of prothrombin time. Prothrombin time and INR should be carefully monitored.
Mechanism
Potentiation of anticoagulant effect
Source: NLP:metronidazole