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Does Oral Anticoagulants Interact with Testosterone?

Oral Anticoagulants and Testosterone have a moderate drug interaction according to U.S. FDA drug labeling data. Changes in anticoagulant activity may occur with androgens. More frequent monitoring of INR and prothrombin time is recommended, especially at initiation and termination of therapy. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Testosterone Class
Androgen
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Oral Anticoagulants and your doctor is considering prescribing Testosterone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oral Anticoagulants+💊 Testosterone(Fortesta)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Androgen
Source
NLP:testosterone

What this means in plain English

Changes in anticoagulant activity may occur with androgens. More frequent monitoring of INR and prothrombin time is recommended, especially at initiation and termination of therapy.

About Oral Anticoagulants and Testosterone

Testosterone is an Androgen. Testosterone is also sold under the brand name Fortesta. Testosterone is applied to the skin. Testosterone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.