HomeTestosteroneTestosterone + Repository Corticotropin

Does Testosterone Interact with Repository Corticotropin?

Testosterone and Repository Corticotropin have a moderate drug interaction according to U.S. FDA drug labeling data. Concurrent use with testosterone may result in increased fluid retention. Use with caution, particularly in patients with cardiac, renal, or hepatic disease. The mechanism involves increased fluid retention. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Testosterone Class
Androgen
Repository Corticotropin Class
Adrenocorticotropic Hormone
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Testosterone and Repository Corticotropin occurs because increased fluid retention. Clinically, this means concurrent use with testosterone may result in increased fluid retention. use with caution, particularly in patients with cardiac, renal, or hepatic disease. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Testosterone and your doctor is considering prescribing Repository Corticotropin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Testosterone(Fortesta)+💊 Repository Corticotropin(Acthar)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Androgen
Drug B class
Adrenocorticotropic Hormone
Source
NLP:testosterone

What this means in plain English

Concurrent use with testosterone may result in increased fluid retention. Use with caution, particularly in patients with cardiac, renal, or hepatic disease.

About Testosterone and Repository Corticotropin

Testosterone is an Androgen, while Repository Corticotropin is an Adrenocorticotropic Hormone. You may recognize them by the brand names Fortesta and Acthar. Testosterone is applied to the skin, whereas Repository Corticotropin is given by intramuscular injection. Testosterone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Increased fluid retention"

📖 Source: NLP:testosterone

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Testosterone and Repository Corticotropin against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.