Does Oral Contraceptives Interact with Bosentan?
CDI records a major classification for Oral Contraceptives and Bosentan. The stored summary is: Bosentan reduces effectiveness of oral, injectable, transdermal, and implantable hormonal contraceptives by decreasing exposure to ethinyl estradiol (31% average, up to 66%) and norethindrone (14% average, up to 56%). The mechanism involves cyp3a and cyp2c9 induction by bosentan increases metabolism of contraceptive hormones. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A and CYP2C9 induction by bosentan increases metabolism of contraceptive hormones
What To Tell Your Doctor or Pharmacist
If you are taking Oral Contraceptives and your doctor is considering prescribing Bosentan (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider