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Does Tranexamic Acid Interact with Oral Contraceptives?

Tranexamic Acid and Oral Contraceptives have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase thrombotic risk associated with combined hormonal contraceptives due to tranexamic acid's antifibrinolytic properties. The mechanism involves additive thrombotic risk from antifibrinolytic effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Tranexamic Acid Class
Antifibrinolytic Agent
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tranexamic Acid and Oral Contraceptives occurs because additive thrombotic risk from antifibrinolytic effect. Clinically, this means concomitant use may increase thrombotic risk associated with combined hormonal contraceptives due to tranexamic acid's antifibrinolytic properties. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Tranexamic Acid and your doctor is considering prescribing Oral Contraceptives (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tranexamic Acid(Tranexamic Acid)+💊 Oral Contraceptives

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Antifibrinolytic Agent
Drug B class
—
Source
NLP:tranexamic acid

What this means in plain English

Concomitant use may increase thrombotic risk associated with combined hormonal contraceptives due to tranexamic acid's antifibrinolytic properties.

What the FDA label says

"Additive thrombotic risk from antifibrinolytic effect"

📖 Source: NLP:tranexamic acid

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.