Home›Oral Contraceptives›Oral Contraceptives + Tovorafenib

Does Oral Contraceptives Interact with Tovorafenib?

Oral Contraceptives and Tovorafenib have a major drug interaction according to U.S. FDA drug labeling data. Tovorafenib may decrease progestin and ethinyl estradiol exposure, leading to contraceptive failure and breakthrough bleeding. Avoid coadministration or use additional nonhormonal contraception. The mechanism involves tovorafenib is a cyp3a inducer that decreases cyp3a substrate exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Tovorafenib Class
Kinase Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Oral Contraceptives and Tovorafenib occurs because tovorafenib is a cyp3a inducer that decreases cyp3a substrate exposure. Clinically, this means tovorafenib may decrease progestin and ethinyl estradiol exposure, leading to contraceptive failure and breakthrough bleeding. avoid coadministration or use additional nonhormonal contraception. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Oral Contraceptives and your doctor is considering prescribing Tovorafenib (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oral Contraceptives+💊 Tovorafenib(Ojemda)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Kinase Inhibitor
Source
NLP:tovorafenib

What this means in plain English

Tovorafenib may decrease progestin and ethinyl estradiol exposure, leading to contraceptive failure and breakthrough bleeding. Avoid coadministration or use additional nonhormonal contraception.

What the FDA label says

"Tovorafenib is a CYP3A inducer that decreases CYP3A substrate exposure"

📖 Source: NLP:tovorafenib

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Oral Contraceptives and Tovorafenib against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.