Does Oxycodone And Aspirin Interact with Ketoconazole?
Oxycodone And Aspirin and Ketoconazole have a moderate drug interaction according to U.S. FDA drug labeling data. CYP3A4 inhibitor may decrease clearance of oxycodone, leading to increased plasma concentrations and prolonged opioid effects. The mechanism involves cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Oxycodone And Aspirin Class
- Nonsteroidal Anti-inflammatory Drug
- Ketoconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Oxycodone And Aspirin and Ketoconazole occurs because cyp3a4 inhibition. Clinically, this means cyp3a4 inhibitor may decrease clearance of oxycodone, leading to increased plasma concentrations and prolonged opioid effects. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Oxycodone And Aspirin and your doctor is considering prescribing Ketoconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider