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Oxycodone And Aspirin

Also known as: Oxycodone And Aspirin

Nonsteroidal Anti-inflammatory DrugPlatelet Aggregation InhibitorCyclooxygenase Inhibitors

Route: Oral

Check Oxycodone And Aspirin Interactions →
16 interactions on record⛔ Black Box Warning

Oxycodone And Aspirin has 16 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Carbamazepine, Heparin. Patients taking Oxycodone And Aspirin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
16
Major
8
Moderate
7

Major (8)

Moderate (7)

Oxycodone And Aspirin + Oxycodoneℹ️Unknown

Drug -Drug Interactions (see PRECAUTIONS) Inhibitors of CYP3A4 Since the CYP3A4 isoenzyme plays a major role in the metabolism of oxycodone and aspirin tablets, drugs that inhibit CYP3A4 activity, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), may cause decreased clearance of oxycodone, which could lead to an increase in oxycodone plasma concentrations. A published study showed that the co-administration of the antifungal drug, voriconazole, increased oxycodone AUC and Cmax by 3.6 and 1.7 fold, respectively. Inducers of CYP450 CYP450 inducers, such as rifampin, carbamazepine, and phenytoin, may induce the metabolism of oxycodone, may cause increased clearance of the drug which could lead to a decrease in oxycodone plasma concentrations.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.