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Does Oxycodone And Aspirin Interact with Phenytoin?

Oxycodone And Aspirin and Phenytoin have a major drug interaction according to U.S. FDA drug labeling data. CYP450 inducer may increase clearance of oxycodone; salicylate can also displace protein-bound phenytoin, decreasing its concentration. The mechanism involves cyp450 induction; protein binding displacement. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Oxycodone And Aspirin Class
Nonsteroidal Anti-inflammatory Drug
Phenytoin Class
Anti-epileptic Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Oxycodone And Aspirin and Phenytoin occurs because cyp450 induction; protein binding displacement. Clinically, this means cyp450 inducer may increase clearance of oxycodone; salicylate can also displace protein-bound phenytoin, decreasing its concentration. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Oxycodone And Aspirin and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oxycodone And Aspirin(Oxycodone And Aspirin)+💊 Phenytoin(Phenytoin Infatabs)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Anti-epileptic Agent
Source
NLP:oxycodone and aspirin

What this means in plain English

CYP450 inducer may increase clearance of oxycodone; salicylate can also displace protein-bound phenytoin, decreasing its concentration.

What the FDA label says

"CYP450 induction; protein binding displacement"

📖 Source: NLP:oxycodone and aspirin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.