Does Oxymetazoline Hydrochloride Interact with Cardiac Glycosides?
Oxymetazoline Hydrochloride and Cardiac Glycosides have a moderate drug interaction according to U.S. FDA drug labeling data. Alpha-adrenergic agonists may impact blood pressure; caution advised when used with cardiac glycosides. The mechanism involves alpha-adrenergic agonist effects on blood pressure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Oxymetazoline Hydrochloride and Cardiac Glycosides occurs because alpha-adrenergic agonist effects on blood pressure. Clinically, this means alpha-adrenergic agonists may impact blood pressure; caution advised when used with cardiac glycosides. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Oxymetazoline Hydrochloride and your doctor is considering prescribing Cardiac Glycosides (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider