Does Pantoprazole Sodium Delayed Release Interact with Methotrexate?
CDI records a major classification for Pantoprazole Sodium Delayed Release and Methotrexate. The stored summary is: Concomitant use of pantoprazole with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and metabolite, possibly leading to toxicities. The mechanism involves elevated and prolonged serum concentrations; mechanism not specified. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Elevated and prolonged serum concentrations; mechanism not specified
What To Tell Your Doctor or Pharmacist
If you are taking Pantoprazole Sodium Delayed Release and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider