Does Paroxetine Interact with Iloperidone?
Paroxetine and Iloperidone have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP2D6 inhibitor that increased iloperidone and P88 metabolite peak concentrations ~1.6 fold, decreased P95 by half. Dose reduction required. The mechanism involves cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Iloperidone Class
- Atypical Antipsychotic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Paroxetine and Iloperidone occurs because cyp2d6 inhibition. Clinically, this means strong cyp2d6 inhibitor that increased iloperidone and p88 metabolite peak concentrations ~1.6 fold, decreased p95 by half. dose reduction required. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Paroxetine and your doctor is considering prescribing Iloperidone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider