Home›Paroxetine›Paroxetine + Zaleplon

Does Paroxetine Interact with Zaleplon?

CDI records a minor classification for Paroxetine and Zaleplon. The stored summary is: Co-administration did not produce any interaction on psychomotor performance. Paroxetine did not alter zaleplon pharmacokinetics, confirming no role of CYP2D6 in zaleplon metabolism. The mechanism involves no significant interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Minor
Zaleplon Class: gamma-Aminobutyric Acid A Receptor Agonist
Management: Generally manageable
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

No significant interaction

What To Tell Your Doctor or Pharmacist

If you are taking Paroxetine and your doctor is considering prescribing Zaleplon (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Paroxetine(Paxil)+💊 Zaleplon(Zaleplon)

Severity & Interaction Details

✅

minor

Minor classification in CDI

This classification is not an individual safety assessment. Ask your pharmacist how the record applies to your medications.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

gamma-Aminobutyric Acid A Receptor Agonist

Source

NLP:zaleplon

What this means in plain English

Co-administration did not produce any interaction on psychomotor performance. Paroxetine did not alter zaleplon pharmacokinetics, confirming no role of CYP2D6 in zaleplon metabolism.

About Paroxetine and Zaleplon

Zaleplon is a gamma-Aminobutyric Acid A Receptor Agonist. Paroxetine is also sold under the brand name Paxil. Both Paroxetine and Zaleplon carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:zaleplon

Share this result:

WhatsApp Text / SMS Email

Also share on:X Facebook

Add more drugs

Check Paroxetine and Zaleplon against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.