Does Paroxetine Hydrochloride Hemihydrate Interact with Cimetidine?
CDI records a moderate classification for Paroxetine Hydrochloride Hemihydrate and Cimetidine. The stored summary is: Cimetidine inhibits cytochrome P450 enzymes, potentially affecting paroxetine metabolism and pharmacokinetics. The mechanism involves cyp450 enzyme inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP450 enzyme inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Paroxetine Hydrochloride Hemihydrate and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider