Home›Paroxetine Hydrochloride Hemihydrate›Paroxetine Hydrochloride Hemihydrate + Pimozide

Does Paroxetine Hydrochloride Hemihydrate Interact with Pimozide?

Paroxetine Hydrochloride Hemihydrate and Pimozide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Paroxetine increases pimozide AUC by 151% and Cmax by 62%, leading to increased QT prolongation risk. Contraindicated due to narrow therapeutic index. The mechanism involves cyp2d6 inhibition by paroxetine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Pimozide Class
Typical Antipsychotic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Paroxetine Hydrochloride Hemihydrate and Pimozide occurs because cyp2d6 inhibition by paroxetine. Clinically, this means paroxetine increases pimozide auc by 151% and cmax by 62%, leading to increased qt prolongation risk. contraindicated due to narrow therapeutic index. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Paroxetine Hydrochloride Hemihydrate and your doctor is considering prescribing Pimozide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Paroxetine Hydrochloride Hemihydrate(Paroxetine)+💊 Pimozide(Pimozide)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Typical Antipsychotic
Source
NLP:paroxetine hydrochloride hemihydrate

What this means in plain English

Paroxetine increases pimozide AUC by 151% and Cmax by 62%, leading to increased QT prolongation risk. Contraindicated due to narrow therapeutic index.

What the FDA label says

"CYP2D6 inhibition by paroxetine"

📖 Source: NLP:paroxetine hydrochloride hemihydrate

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Paroxetine Hydrochloride Hemihydrate and Pimozide against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.