Does Perphenazine And Amitriptyline Hydrochloride Interact with Fluoxetine?
CDI records a major classification for Perphenazine And Amitriptyline Hydrochloride and Fluoxetine. The stored summary is: Fluoxetine inhibits cytochrome P450 2D6 and has a long half-life; at least 5 weeks must elapse before initiating amitriptyline after fluoxetine withdrawal. The mechanism involves inhibition of cytochrome p450 2d6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Perphenazine And Amitriptyline Hydrochloride Class
- Phenothiazine
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of cytochrome P450 2D6
What To Tell Your Doctor or Pharmacist
If you are taking Perphenazine And Amitriptyline Hydrochloride and your doctor is considering prescribing Fluoxetine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider