Does Perphenazine And Amitriptyline Hydrochloride Interact with Sertraline?
CDI records a moderate classification for Perphenazine And Amitriptyline Hydrochloride and Sertraline. The stored summary is: Sertraline inhibits cytochrome P450 2D6; caution is indicated in coadministration with amitriptyline and dose adjustments may be necessary. The mechanism involves inhibition of cytochrome p450 2d6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Perphenazine And Amitriptyline Hydrochloride Class
- Phenothiazine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of cytochrome P450 2D6
What To Tell Your Doctor or Pharmacist
If you are taking Perphenazine And Amitriptyline Hydrochloride and your doctor is considering prescribing Sertraline (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider