Perphenazine And Amitriptyline Hydrochloride + Topiramate Interaction
Moderateinteraction on record
Description
Topiramate may increase amitriptyline concentration; amitriptyline dose adjustments should be made based on clinical response rather than plasma levels.
Mechanism
Inhibition of amitriptyline metabolism
Source: NLP:perphenazine and amitriptyline hydrochloride