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Does Pitavastatin Magnesium Interact with Erythromycin?

Pitavastatin Magnesium and Erythromycin have a major drug interaction according to U.S. FDA drug labeling data. Erythromycin significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. Dosage should not exceed 1 mg once daily. The mechanism involves increased pitavastatin exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Pitavastatin Magnesium Class
HMG-CoA Reductase Inhibitor
Erythromycin Class
Macrolide
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Pitavastatin Magnesium and Erythromycin occurs because increased pitavastatin exposure. Clinically, this means erythromycin significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. dosage should not exceed 1 mg once daily. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Pitavastatin Magnesium and your doctor is considering prescribing Erythromycin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Pitavastatin Magnesium(Zypitamag)+💊 Erythromycin

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
HMG-CoA Reductase Inhibitor
Drug B class
Macrolide
Source
NLP:pitavastatin magnesium

What this means in plain English

Erythromycin significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. Dosage should not exceed 1 mg once daily.

What the FDA label says

"Increased pitavastatin exposure"

📖 Source: NLP:pitavastatin magnesium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.