Does Probenecid And Colchicine Interact with Indomethacin?
Probenecid And Colchicine and Indomethacin have a moderate drug interaction according to U.S. FDA drug labeling data. Probenecid increases mean plasma elimination half-life and plasma concentrations of indomethacin; use lower dosages cautiously. The mechanism involves decreased renal excretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Probenecid And Colchicine Class
- Alkaloid
- Indomethacin Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Probenecid And Colchicine and Indomethacin occurs because decreased renal excretion. Clinically, this means probenecid increases mean plasma elimination half-life and plasma concentrations of indomethacin; use lower dosages cautiously. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Probenecid And Colchicine and your doctor is considering prescribing Indomethacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider