Probenecid And Colchicine has 17 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methotrexate, Nonselective Beta-Adrenergic Antagonists, Penicillin. Patients taking Probenecid And Colchicine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 3
- Moderate
- 13
- Minor
- 1
Major (3)
- Probenecid And Colchicine + Methotrexate— Probenecid increases plasma concentrations of methotrexate in animals and humans.
- Probenecid And Colchicine + Nonselective Beta-Adrenergic Antagonists— Probenecid elevates plasma concentrations of beta-lactams, increasing incidence of adverse reactions including psychic d…
- Probenecid And Colchicine + Penicillin— Probenecid elevates plasma concentrations of penicillin, increasing incidence of adverse reactions including psychic dis…
Moderate (13)
- Probenecid And Colchicine + Acetaminophen— Probenecid increases mean plasma elimination half-life and plasma concentrations of acetaminophen; use lower dosages cau…
- Probenecid And Colchicine + Acetazolamide— Probenecid decreases renal excretion of conjugated sulfonamides, significantly increasing total sulfonamide plasma level…
- Probenecid And Colchicine + Indomethacin— Probenecid increases mean plasma elimination half-life and plasma concentrations of indomethacin; use lower dosages caut…
- Probenecid And Colchicine + Ketamine— Probenecid significantly prolongs ketamine anesthesia.
- Probenecid And Colchicine + Ketoprofen— Probenecid increases mean plasma elimination half-life and plasma concentrations of ketoprofen; use lower dosages cautio…
- Probenecid And Colchicine + Lorazepam— Probenecid increases mean plasma elimination half-life and plasma concentrations of lorazepam; use lower dosages cautiou…
- Probenecid And Colchicine + Meclofenamate— Probenecid increases mean plasma elimination half-life and plasma concentrations of meclofenamate; use lower dosages cau…
- Probenecid And Colchicine + Naproxen— Probenecid increases mean plasma elimination half-life and plasma concentrations of naproxen; use lower dosages cautious…
- Probenecid And Colchicine + Pyrazinamide— Pyrazinamide antagonizes the uricosuric action of probenecid.
- Probenecid And Colchicine + Rifampin— Probenecid increases mean plasma elimination half-life and plasma concentrations of rifampin; use lower dosages cautious…
- Probenecid And Colchicine + Salicylates— Salicylates antagonize the uricosuric action of probenecid.
- Probenecid And Colchicine + Sulindac— Probenecid increases plasma levels of sulindac and sulfone metabolite, and sulindac modestly reduces probenecid's uricos…
- Probenecid And Colchicine + Thiopental— Patients receiving probenecid require significantly less thiopental for anesthesia induction, and anesthesia is signific…
Minor (1)
- Probenecid And Colchicine + Theophylline— Falsely high readings for theophylline reported in vitro when therapeutic concentrations combined with probenecid using …